Massachusetts, ANI. Cancer treatment still remains a major challenge for science. It is believed that if the conditions are right, the body’s T-cells work to identify and kill cancer cells. But it has also been found that in most cancer patients, these T-cells are unable to do their job when they are in a tumor-bearing environment. This research has been published in the ‘Immunity Journal’.

In view of these conditions, scientists are now trying to find out how to activate the sluggish T-cells so that they can be used for treatment. Much of this research, especially in cancer immunotherapy, has focused on finding out how to directly activate T-cells. But researchers at MIT have now discovered a new way in which T-cells can be activated indirectly by mobilizing cooperative immune cells, called dendritic cells.

Identification of helpful cells of T-cells: In this new study, researchers have identified a specific group of dendritic cells that activate T-cells in a very specific way. These dendritic cells engulf themselves in the patient’s tumor proteins, and increase the activation of T-cells by becoming pseudo-cancerous cells. According to the MIT researchers, we know that dendritic cells are important for the anti-tumor immune response, but we didn’t know exactly what happens in dendritic cells that prepares them to be appropriately activated against tumors. Is.

Find out the specific role of dendritic cells: Normally, when a tumor begins to form, it secretes a cancer-causing protein, which is recognized by T-cells as a foreign substance. In this situation, sometimes T-cells kill the tumor before it becomes bigger. Whereas another condition also occurs that the tumor starts secreting chemical signals, due to which the T-cells become inactive and the tumor starts growing rapidly.

Denditic cells help activate tumor-fighting T-cells, but there are many different types of dendritic cells and their specific role in activating T-cells is not well understood. So, scientists at MIT sought to find out which types of dendritic cells could activate T-cells to successfully kill tumors.

In mice experiments, it was found that DC1 cells are the most suitable dendritic cells, which are essential for anti-tumor immunity and they react with T-cells to enable them to kill cancer cells. However, it was also found that DC1 cells are not essential for tumor reduction.

Edited By: Neel Rajput